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drug discovery

A collection of 38 posts

Open Targets

How Open Targets is investigating 100 chromatin-related disorders | Rare Disease Day 2021

[5 minute read] Sebastian Gerety is a Senior Staff Scientist at the Wellcome Sanger Institute who oversees the the 100 chromatin-related disorders project. In honour of Rare Disease Day 2021, he told us about what they have been working on.

Sebastian Gerety
Open Targets Platform

How we improved our clinical trial curation during the COVID-19 lockdown

Learn how we leveraged the wide range of expertise amongst our lab-based experimental research colleagues to make valuable contributions to the Open Targets Platform and our target validation projects.

Ellie McDonagh
Open Targets Platform

The importance of Autophagy in drug discovery

Explore Reactome's new autophagy pathway and how it relates to drug discovery and the Open Targets Platform

Thawfeek M Varusai
coronavirus infectious disease

Open Targets releases our COVID-19 Target Prioritisation Tool

Open Targets is excited to introduce our COVID-19 Target Prioritisation Tool - http://covid19.opentargets.org/ - an interactive web portal allows users to explore host and viral targets and potential COVID-19 treatments

Andrew Hercules
release notes

Open Targets Platform 20.04 has been released!

We have a new release of the Open Targets Platform with new target safety data, new target tractability modalities, more chemical probes and new associations.

Denise Carvalho-Silva
Open Targets Genetics

GWAS causal inference in Open Targets

Finding GWAS causal inference for target identification and prioritisation using Open Targets Genetics and the Open Targets Platform.

David Ochoa, Maya Ghoussaini
Q&A

Special Q&A with Gosia Trynka, Open Targets Experimental Science director

We're delighted to have caught up with Gosia Trynka, our new Experimental Science director, for a very special Q&A on Open Targets science and more.

Gosia Trynka, Denise Carvalho-Silva
release notes

Open Targets Platform: release 20.02 is out

We have a new release of the Open Targets Platform with a brand new data source, Open Targets Genetics Portal, more chemical probes and new intOGen data.

Denise Carvalho-Silva
Cancer

An Open Targets Away Day with The Institute of Cancer Research

Open Targets meets colleagues at the Institute of Cancer Research in London: potential collaboration ahead of us.

Ian Dunham, David Hulcoop
ontology

EFO3: A community-driven ontology to advance clinical discoveries

In the 19.11 release of the Open Targets Platform, we moved from EFO2 to EFO3. Here we explore what the new disease ontology means to Open Targets.

David Ochoa, Denise Carvalho-Silva, Zoë May Pendlington, Paola Roncaglia
Open Targets Platform

Using ChEMBL for target identification and prioritisation

Open Targets Q&A on the identification of cancer driver genes and their mechanism of action using intOGen. Using ChEMBL for target identification and prioritisation

Fiona Hunter, Denise Carvalho-Silva
release notes

Open Targets Platform: release 19.11 is out

We have a new release of the Open Targets Platform: new EFO3, FDA pharmacovigilance data, new chemical probes, more targets, more evidence and associations.

Denise Carvalho-Silva
A-Z

From antibody to zinc finger: an A-Z of Open Targets

As scientists discover our freely available resources, it’s time to take a closer look at the terms that matter to Open Targets. November is time for H.

Denise Carvalho-Silva
release notes

Open Targets Platform: release 19.09 is out

We have a new release of the Open Targets Platform: more target-disease associations, more chemical probes and target enabling packages, and updated Elasticsearch.

Denise Carvalho-Silva
A-Z

From antibody to zinc finger: an A-Z of Open Targets

As users discover our freely available resources, it’s time to take a closer look at the terms that matter to Open Targets. This time we have a double bill: F and G.

Denise Carvalho-Silva
release notes

Open Targets Platform: release 19.06 is out

We have a new release of the Open Targets Platform: more target safety information and new target-disease associations are some of the highlights in release 19.06.

Denise Carvalho-Silva
Q&A

Using CRISPR priority score to identify targets in cancer drug discovery

Open Targets Q&A on the first set of CRISPR screen results in cancer for target identification and prioritisation in drug discovery.

Fiona Behan, Denise Carvalho-Silva
release notes

Open Targets Platform: release 19.04 is out

We have a new release of the Open Targets Platform: CRISPR-Cas9 data and target safety information are some of the highlights in release 19.04.

Denise Carvalho-Silva
A-Z

From antibody to zinc finger: an A-Z of Open Targets

As users discover our freely available resources, it’s time to take a closer look at the terms that matter to Open Targets. March is time for E.

Denise Carvalho-Silva
release notes

Open Targets Platform: release 19.02 is out

Our latest release of the Open Targets Platform is out. We have more targets, more diseases, more evidence, more associations, and fixed some bugs too.

Denise Carvalho-Silva
A-Z

From antibody to zinc finger: an A-Z of Open Targets

As users discover our freely available resources, it’s time to take a closer look at the terms that matter to Open Targets. It's D-time.

Denise Carvalho-Silva
release notes

Open Targets Platform: new release is out

The latest release of the Open Targets Platform is out. We have more evidence, new targets, new diseases and new associations, plus data from Probe Miner.

Denise Carvalho-Silva
Open Targets Platform

Get to know the Reactome enhanced pathway visualisations

Open Targets Q&A on the new Reactome pathway visualisations: scalable, interactive textbook-style diagrams in SVG format, freely downloadable and editable.

Konstantinos Sidiropoulos, Antonio Fabregat, Denise Carvalho-Silva
Europe PMC

How Europe PMC can help you find associations between genes and diseases

Open Targets Q&A on how you can stay up-to-date with the latest advances in drug discovery.

Maria Levchenko, Denise Carvalho-Silva
release notes

The latest release of the Open Targets Platform is out!

We have a new release of the Open Targets Platform. New data source for target-disease associations, new drug visualisations, cancer biomarkers, and more.

Denise Carvalho-Silva
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